Saltigo pharma solutions – Your partner for custom manufacturing

Our advanced technology toolbox for your complex molecules:

Metathesis

• Seamless scale-up: From lab to multi-ton production with catalysts optimized for both efficiency and selectivity
• Proven expertise in cross- and ring-closing metathesis for functionalized di-esters and di-acids (C18-C20), macrocycles, and complex pharma building blocks

Flow Chemistry

• Safe and precise execution of highly exothermic reactions
• Ensure reproducible quality, precise control of residence time and mixing for optimal yields

High Pressure Hydrogenation

• Hydrogenations from lab to full scale including the use of green hydrogen for sustainable manufacturing
• Selective and asymmetric reductions, batch and conti up to 200 bar, 320°C

Chlorination

• Versatile chlorinations (Cl₂, PCl₃/Cl₂, PCI₅, POCl₃, SOCl₂, SO₂Cl₂) for key pharmaceutical building blocks
• Pressurized chlorinations up to 6 bar

Phosgenation

• In-house phosgene generation for maximum supply security
• Complex downstream chemistry for demanding pharma intermediates

Carbonylation

• Batch and continuous carbonylation up to 40 bar
• Safe CO handling and reliable downstream quench/separation

Fluorination

• Halex and HF chemistry for targeted fluorine introduction into pharmaceutical intermediates
• Backward integration into HF for security of supply

Nitration

• Nitrations with 98% fuming nitric acid and oleum under the strictest safety standards
• Continuous process options for sensitive intermediates

Cryogenic Chemistry

• Cryogenic processes down to −100 °C, e.g., for selective lithiations
• Essential for temperature-sensitive building blocks

Oxidation

• Scalable oxidations with H₂O₂, peracids and persulfates
• Low-temperature reactions such as Swern oxidations

Bromination

• Large-scale brominations with backward integration into Bromine/HBr supply
• Efficient and safe processing

Simmons-Smith Cyclopropanation

• Over 20 years of expertise in sensitive organozinc chemistry
• Infrastructure for off-gas and special waste handling

This is just a selection of our proven technologies. Beyond that, we adapt and expand our toolbox to meet the specific requirements of our partners.
Let’s talk about your needs!

1. Confidentiality Agreement & Inquiry/Scoping
   Customer request with target molecule, specifications, volumes, application, regulatory needs, timeline, and cost frame.
   
   
2. Evaluation & Proposal
   Feasibility check of chemistry, assets, safety, and environmental aspects.
   ➔ Initial feedback within 5 days
   ➔ Mutual agreement to continue: Price indication within 10 days
   
   
3. Process Development & Pilot
   Further evaluation and binding offer
   Lab development, optimization, and validation, followed by pilot batches if needed.
   Output: lab process, plant concept, investment estimate, binding offer, and sample material.
   
   
4. Scale-up & Commercial Production
   Transfer to full-scale manufacturing at required volumes.
   
   
5. Aftercare & Optimization
   Continuous process improvements to enhance efficiency, reduce costs, and support sustainability.

From the very beginning, our experienced project teams work with you in a goal-oriented way – fast, focused, and reliable.

Every requirement is unique. In a personal meeting, we take a close look at your challenge and shape an approach tailored to your needs.

Get in touch with one of our experts at CPHI and discover how Saltigo can support your next project.