Ion exchange resins and adsorbers for the pharma and biotechnology industry
Lewatit® ion exchange resins and adsorbers are in widespread use in a variety of applications for industries such as bioprocessing and biotechnology, pharmaceutical, biopharmaceutical, nutraceutical and food. Their end products range from food and animal feeds to active pharmaceutical ingredients (APIs) that are used in medicinal products. Ion exchange resins and adsorbers help in the treatment and cleaning of products obtained from biomass by providing support with capture, purification including fine purification, and chromatography or through their use in, e.g., detoxification, conversion, decolorization or demineralization of biomolecules. As well as being used in cleaning, ion exchangers can therefore also help to stabilize products such as amino acids, proteins, vitamins, alkaloids and other active ingredients. In addition, ion exchange resins have become established as substrates for the transportation of active substances in either classic or ground form. Enzyme-catalyzed reactions can also be carried out with the aid of fixed enzymes, whereby the ion exchange matrix offers numerous benefits for the catalysis process.
Water of different qualities is required as a solvent in manufacturing processes in the pharmaceutical and bioprocessing industries. Lewatit® ion exchanger types can be combined to beneficial effect to meet different quality requirements for softening or demineralization of the necessary process water. Our LewaPlus® design software can model various combinations on a made-to-measure basis and thus provides users with maximum confidence that they will obtain the optimum treatment solution. It can also deal with waste water from production facilities through reliable and thorough treatment.
For these and other applications, LANXESS offers a comprehensive range of special ion exchange resins that are tailored to specific requirements. Find the best product for your needs now.
Antibiotics are derived from fermentation or chemical synthesis. Lewatit® resins and adsorbents are utilized in capture and purification, e.g., within cephalosporine, streptomycin, gentamycin, neomycin, erythromycin, and vancomycin production.
Supported processes are various, ranging from isolation (e.g., Lewatit® VP OC 1064 MD PH, Lewatit® PH 8021), decolorization (e.g., Lewatit® PH 7061), conversion (e.g., Lewatit® PH 1061, Lewatit® PH 7061), demineralization and polishing (e.g., Lewatit® PH 3021).
Amino acids are the building blocks of proteins and play a key role in the existence of living organisms. They are produced in bioreactors by bacterial fermentation of carbohydrates. Industrial purification of most types of amino acids often involves ion exchange resins and adsorbents steps.
They can be separated from each other by strong acidic cation exchange resins (e.g., Lewatit® PH 2061 MDS), captured from a complex fermentation broth mixture by separation from non-ionic impurities (e.g., Lewatit® PH 1061, Lewatit® PH 5021) and decolorized (Lewatit® VP OC 1064 MD PH). Selection of resin types is based on type and charge of amino acid.
Lewatit® supports the production of amino acids, ranging from BCAA’s (branched-chain amino acids) to unbranched ones, such as lysin, threonine, tryptophane, histidine, arginine, serine, and many more.
A large selection of marketed pharmaceuticals is based on polysaccharides, and derive either from fermentation pro¬cesses or natural extracts. One well known product class originating from animal source are GAG’s (glycosylated amino glycans), such as heparin, chondroitin, nadroparin, dermatan and others as well. Their capture and purification is typically done with ion exchange resins (Lewatit® PH 1074 HEP) to allow high yield, activity, and purity of end products.
An important feature of resin involves a specially designed macroporous structure to allows best conditions for adsorption and desorption. Lewatit® PH 1074 HEP is added to the digestion mixture, takes up the GAG and is finally separated from solution. Afterwards elution of, e.g., heparin, from ion exchange resin is done with brine.
DOWNLOADS
- Lewatit® Product Guide(PDF, 5.4 MB)
- Lewatit® ion exchange resins and adsorbents for capture and purification of biomolecules(PDF, 5.8 MB)
- Flyer Lewatit® PH 1074 HEP(PDF, 424.9 KB)
- Start up Conditions for Lewatit® Ion Exchange Resins and adsorbents for capture and purification of biomolecules(PDF, 957.2 KB)
